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Genomic Intelligence DNA Predictions

Predict promoters, splice sites, enhancers, chromatin, and gene expression from DNA via a hosted model API

Source Download skill
Repository
K-Dense-AI/scientific-agent-skills
Stars
55,780
Licence
MIT
Files
6 files

What it does

Once installed, the agent can send a gene symbol, genomic region, or DNA/FASTA sequence to Genomic Intelligence's hosted DNA language models and return structured predictions: promoter regions, splice donor/acceptor sites, enhancer activity, chromatin state, expression as log TPM, and de-novo gene annotation. Nothing runs on your computer beyond simple API calls, so no GPU or model weights are needed. It is not for local sequence alignment, variant calling, or file handling; those belong to tools like BioPython or bcftools.

Great for

  • Researchers exploring regulatory features of a DNA region before running wet-lab experiments
  • Bioinformatics students who want quick model-based predictions without installing heavy tools
  • Developers building pipelines that call a hosted genomics prediction API

Skip it if

  • Clinical or diagnostic decisions, since the skill is explicitly for research and development use only
  • Variant calling or sequence alignment, which this skill does not perform (use BioPython or bcftools)
  • Sensitive or confidential sequence data, because sequences are sent to a third-party hosted service over the network

Try asking

  • “Find the promoter regions in this 5 kb genomic region: chr1:100000-105000”
  • “Predict log TPM expression for the BRCA1 gene in HepG2 cells”
  • “Annotate the transcripts in this FASTA sequence de novo”
  • “Score enhancer activity and chromatin state for this 1,000 bp DNA sequence”
Step-by-step guide: how to use Genomic Intelligence DNA PredictionsInstall, first run, examples, tips and FAQs

Install in 3 steps

  1. 1

    Download the skill

    The ZIP contains the 6 original files, the MIT licence and an attribution note.

    genomic-intelligence.zip
  2. 2

    Add it to your agent

    Claude Code (all projects)

    mkdir -p ~/.claude/skills && unzip genomic-intelligence.zip -d ~/.claude/skills/

    Claude Code / Agent SDK (this project only)

    mkdir -p .claude/skills && unzip genomic-intelligence.zip -d .claude/skills/

    Claude apps (web/desktop): Settings → Capabilities → Skills → Upload skill, and choose the ZIP.

  3. 3

    Ask for the task

    No special command needed — the agent reads the skill's description and loads it when your request matches. Try one of the prompts above.

Get better results

  • Use the hosted MCP server where supported, since it works without a key and keeps large sequences out of the context window
  • Check each task's minimum and maximum sequence length and required parameters (for example, expression needs a tss_index unless the sequence is exactly 9,198 bp) before submitting
  • Never paste a real API key into chats or commit it; store it in the GI_API_KEY environment variable and expect 429 errors when rate caps are hit

What's inside

  • references/api-and-auth.md
  • references/mcp.md
  • references/review.md
  • references/sequence-acquisition.md
  • references/tasks.md
  • SKILL.md

Redistributed unmodified from K-Dense-AI/scientific-agent-skills under the MIT licence. The assessment was drafted with AI from the skill's files on 2026-10-29. Skills can instruct your agent to run code — read SKILL.md and any scripts before installing.